CAR-T and Cell Therapy
CAR-T Cell Therapy
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What is CAR-T
(chimeric antigen
receptor-T) cell
therapy? -
Candidates for
CAR-T therapy -
CAR-T Therapy
Process -
Side Effects of
CAR-T Therapy -
Emergency Situations
After CAR-T Infusion
What is CAR-T(chimeric antigen receptor-T) cell therapy?
CAR-T cell therapy is a type of treatment where your own immune cells, specifically T cells, are modified in a lab to better fight cancer. These cells are equipped with a feature called a Chimeric Antigen Receptor (CAR), which helps them recognize and attack specific proteins on the surface of cancer cells. Once these modified CAR-T cells are put back into your body, they seek out the cancer cells and work to destroy them. This therapy is a form of immunotherapy, which means it uses your body's own immune system to combat cancer.
Candidates for CAR-T therapy
Adults with large B-cell lymphoma that has come back or hasn't responded to treatment
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1.
Patients whose cancer has come back or hasn't responded after two or more types of systemic therapy.
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2.
Patients whose cancer has come back after a hematopoietic stem cell transplant.Patients whose cancer has come back after a hematopoietic stem cell transplant.
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3.
Patients who aren't eligible for or can't have an autologous hematopoietic stem cell transplant.
Children and young adults up to 25 years old with B-cell acute lymphoblastic leukemia
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1.
Patients who haven't gone into remission after initial treatment.
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2.
Patients whose cancer has come back after an allogeneic hematopoietic stem cell transplant.
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3.
Patients whose cancer has come back or hasn't responded after two or more types of systemic therapy.
CAR-T Therapy Process
Side Effects of CAR-T Therapy
You might experience side effects within a few weeks after receiving CAR-T therapy.
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Cytokine Release Syndrome (CRS)
high fever, chills, muscle and joint pain, nausea, vomiting, diarrhea, excessive sweating, rashes, loss of appetite, fatigue, headaches, dizziness, confusion, and weakness
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Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS)
alertness or consciousness, delirium, anxiety, dizziness, tremors, headaches, confusion, agitation, seizures, difficulty speaking or understanding speech, and loss of balance
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Infections
feeling of warmth, fever, chills, or shivering
Emergency Situations After CAR-T Infusion
If you experience any of the following symptoms after receiving CAR-T therapy, call 119 and go to the emergency room as soon as possible.
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📞 Emergency Telephone Number
119
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📞 Seoul St. Mary’s Hospital
1588-1511
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Dyspnea
(Difficulty breathing) -
Severe myalgia or arthralgia (Severe muscle or joint pain)
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Rigors (Shaking chills)
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Profound hypotension
(Severe low blood pressure) -
Fever higher than
38 degrees Celsius -
Vertigo / syncope (Dizziness or fainting)
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Confusion /
headache -
Severe nausea,
vomiting, diarrhea